This episode explains the science of motivation and drive. I describe how dopamine-- a chemical we all make in our brain, underlies our desire for and pursuit of our goals, as well as our capacity to move and experience pleasure. I describe how we can leverage specific behaviors, reward schedules and dopamine-prolactin balance to help ensure we can maintain motivation and capacity for pleasure over the long term. I also discuss dopamine in the context of ADHD, craving and addiction, and some absolutely amazing results about specificity of drug effects based purely on belief.Thank you to our sponsors:Athletic Greens - https://athleticgreens.com/huberman Headspace - http://headspace.com/specialoffer Magic Spoon - http://magicspoon.com/huberman Our Patreon page:https://www.patreon.com/andrewhuberman Supplements from Thorne:http://www.thorne.com/u/huberman Link to study:Effects of expectation on specificity of stimulant effects: https://pubmed.ncbi.nlm.nih.gov/33734725/ Timestamps below.00:00:00 Introduction 00:04:22 Announcement: Spanish Subtitles 00:05:06 Emotions, Addiction & Mindset 00:06:22 Motivation & Movement: The Dopamine Connection 00:07:29 A Double-Edged Dopamine Blade 00:08:56 Dopamine Fundamentals: Precursor to Adrenalin 00:10:15 The Reward Pathway: An Accelerator & A Brake 00:12:10 Motivation= Pleasure Plus Pain 00:14:14 The Dopamine Staircase: Food, Sex, Nicotine, Cocaine, Amphetamine 00:16:15 Subjective Control of Dopamine Release 00:17:40 Social Media and Video Games 00:18:15 Addiction & Dopamine: Progressively Diminishing Returns 00:18:48 Novelty, Sensation-Seeking & Anticipation 00:20:15 Craving: Part Pain, Part Pleasure & Pain Always Prevails 00:23:11 Desire Scales With Pain: The Yearning Function 00:24:43 The Croissant Craving Circuit 00:25:45 “Here and Now” Molecules: Serotonin, Bliss & Raphe Nucleus 00:26:26 In Your Skin Or Out In the World 00:27:25 Cannabinoids Lethargy & Forgetfulness 00:28:15 The Almond Meditation 00:29:30 Drugs That Shift Exteroception Versus Interoception 00:30:36 Emotional Balance, Active & Passive Manipulation 00:32:36 Procrastination: Leveraging Stress, Breathing, Caffeine, L-Tyrosine, Prescription Drugs 00:37:04 When Enough Is Never Enough; How Dopamine Undermines Itself 00:38:58 Dopamine-Prolactin Dynamics: Sex, Reproduction & Refractory Periods 00:40:30 The Coolidge Effect: Novelty-Induced Suppression of Prolactin 00:42:22 Vitamin B6, Zinc As Mild Prolactin Inhibitors 00:43:25 Schizophrenia, Dopamine Hyperactivity and Side Effects of Anti-Dopaminergic Drugs 00:45:08 Prolactin, Post-Satisfaction “Lows” & Extending the Arc of Dopamine 00:48:00 The Chemistry of “I Won, But Now What?” 00:49:00 Healthy Emotional Development: Child and Parent 00:50:03 Never Say “Maybe” (Reward Prediction Error) 00:52:02 Surprise! 00:52:59 Are You Suppressing Your Drive and Motivation By Working Too Late? 00:54:50 Disambiguating Pleasure and Drive: Dopamine Makes Us Anti-Lazy 00:58:00 Beta-Phenylethylamine (PEA), & Acetyl L-Carnitine 01:00:00 Attention Deficit Disorders, Cal Newport Books, Impulsivity & Obesity 01:03:55 Leveraging Dopamine Schedules 01:05:22 Subjective Control of Dopamine and Drug Effects: The “Adderall” Experiment 01:09:03 Caffeine May Protect Dopamine Neurons, Methamphetamine Kills Them 01:10:57 Nicotine: Dopamine, Possible Neuroprotection, Prolactin Increase 01:11:53 Gambling, Intermittent Reinforcement, & Persistent Goal Seeking (Bad and Good) 01:14:14 Intermittent Halting of Celebration; Enjoy Your Wins, But Not All of Them 01:18:38 A Story Example of Intermittent Reward to Maintain Long-Term Drive and Motivation 01:21:25 Corrections & Notes About Spanish Captions & Other Languages Soon 01:24:00 Synthesis & Framework, Zero-Cost Support & A Note About SponsorsPlease note that The Huberman Lab Podcast is distinct from Dr. Huberman's tea
Comments